Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 2.478


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_165565006 5.055 POU2F1
POU class 2 homeobox 1
chr1_+_165564904 4.553 NM_001198783
POU2F1
POU class 2 homeobox 1
chr4_+_100714995 4.497 MTTP
microsomal triglyceride transfer protein
chr1_-_1701313 3.812 NM_001198994
NADK
NAD kinase
chr16_-_54424517 3.462 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr21_+_41663853 3.243 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr9_+_134843918 3.188 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr5_+_27508139 3.093 LOC643401
hypothetical protein LOC643401
chr6_-_138862273 3.079


chr4_+_74493918 2.891 ALB
albumin
chr8_+_39890484 2.672 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr4_+_74493174 2.504 ALB
albumin
chr2_+_169367345 2.477 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr6_+_24465109 2.471 NM_181337
KAAG1
kidney associated antigen 1
chrX_-_55037235 2.357 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr1_-_24112345 2.314 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr16_+_70646008 2.271 NM_001126102
NM_005143
HP

haptoglobin

chr12_+_25096472 2.253 NM_006152
LRMP
lymphoid-restricted membrane protein
chr17_+_24394281 2.236 PIPOX
pipecolic acid oxidase
chr17_-_76720342 2.141 AATK
apoptosis-associated tyrosine kinase
chr4_+_74493331 2.126 ALB
albumin
chr6_+_132000134 2.112 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr17_+_24394043 2.095 NM_016518
PIPOX
pipecolic acid oxidase
chr12_-_121767272 2.024 NM_006018
GPR109B
G protein-coupled receptor 109B
chr6_-_108252200 2.023 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr19_-_5789740 1.913 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr11_-_16380967 1.909 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr10_+_7785360 1.881 ITIH2
inter-alpha (globulin) inhibitor H2
chr4_+_74493266 1.777 ALB
albumin
chr16_-_45339605 1.753 NM_182493
MYLK3
myosin light chain kinase 3
chr17_+_3324096 1.747 NM_001128085
ASPA
aspartoacylase
chr10_+_7785235 1.727 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr6_-_43384507 1.719 NM_206922
CRIP3
cysteine-rich protein 3
chr10_+_7785290 1.707 ITIH2
inter-alpha (globulin) inhibitor H2
chr12_-_14887648 1.700 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr2_+_113601616 1.674 IL1RN
interleukin 1 receptor antagonist
chr1_+_57093030 1.654 NM_000562
C8A
complement component 8, alpha polypeptide
chr2_+_233443237 1.627 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr3_+_186529376 1.613 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr4_+_74493218 1.601 ALB
albumin
chr2_+_128644510 1.586 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr10_+_114123765 1.564 ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_+_7785331 1.549 ITIH2
inter-alpha (globulin) inhibitor H2
chr5_+_140709907 1.540 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr2_+_113601608 1.536 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr19_-_53081326 1.527 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr12_-_121753795 1.508 NM_177551
GPR109A
G protein-coupled receptor 109A
chrX_+_7147471 1.508 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr12_+_102859354 1.477 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr4_+_74493301 1.441 ALB
albumin
chr4_+_17125885 1.406 NM_001079827
CLRN2
clarin 2
chr6_+_88021644 1.394 ZNF292
zinc finger protein 292
chr1_+_559129 1.374


chr7_+_37689903 1.368


chr14_+_22859236 1.362 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr5_-_43448174 1.360 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr3_+_122794859 1.355 NM_016298
FBXO40
F-box protein 40
chr16_+_82540172 1.348 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr14_-_106240998 1.345 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_50347176 1.328 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr12_+_25096755 1.252 LRMP
lymphoid-restricted membrane protein
chr7_+_129057152 1.238 NM_001040110
NRF1
nuclear respiratory factor 1
chrX_+_36163971 1.227 NM_001098843
CXorf30
chromosome X open reading frame 30
chr13_-_27441143 1.193 CDX2
caudal type homeobox 2
chr10_+_114123828 1.159 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_42892195 1.155 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_-_238813365 1.139 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr6_+_167445284 1.133 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr2_-_238813284 1.127 HES6
hairy and enhancer of split 6 (Drosophila)
chr13_-_27441290 1.105 NM_001265
CDX2
caudal type homeobox 2
chr10_-_11614279 1.103 NM_001080491
USP6NL
USP6 N-terminal like
chr14_+_38772870 1.091 NM_054024
MIA2
melanoma inhibitory activity 2
chr13_+_108079570 1.088 NM_001198950
MYO16
myosin XVI
chr22_+_16423147 1.081 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr1_+_559618 1.080


chr3_-_57209319 1.047 NM_003865
HESX1
HESX homeobox 1
chr6_+_131190237 1.047 NM_001195597
LOC285733
hypothetical LOC285733
chr14_-_106241445 1.034 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chrX_+_65152004 1.014


chr1_-_181889070 1.008 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr6_-_138862271 1.006 NM_001144060
NHSL1
NHS-like 1
chr2_+_68445821 0.995 NM_002664
PLEK
pleckstrin
chr2_+_68445936 0.992 PLEK
pleckstrin
chr6_+_64344307 0.987 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_-_31668476 0.985 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr7_+_80105907 0.971 CD36
CD36 molecule (thrombospondin receptor)
chr4_-_41445479 0.941 PHOX2B
paired-like homeobox 2b
chr1_+_43063817 0.924 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr6_+_32515596 0.924 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr10_-_52315436 0.922 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr3_-_102522093 0.921 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr1_-_158759606 0.917 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr6_+_64414389 0.915 NM_015153
PHF3
PHD finger protein 3
chr9_-_99740243 0.910 NM_197978
HEMGN
hemogen
chr10_-_73518772 0.908 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr3_-_150422474 0.907 NM_000096
CP
ceruloplasmin (ferroxidase)
chr3_-_173723754 0.885 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr10_+_91488704 0.879 KIF20B
kinesin family member 20B
chr4_+_88076418 0.872


chr16_+_28850760 0.867 NM_001178098
NM_001770
CD19

CD19 molecule

chr3_-_69381995 0.849 FRMD4B
FERM domain containing 4B
chr9_-_85773899 0.846 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr7_+_80105858 0.830 CD36
CD36 molecule (thrombospondin receptor)
chr3_+_99733432 0.830 NM_005290
GPR15
G protein-coupled receptor 15
chr17_-_64649608 0.828 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr6_+_26264537 0.827 NM_005321
HIST1H1E
histone cluster 1, H1e
chr12_+_49155798 0.825 LARP4
La ribonucleoprotein domain family, member 4
chr14_-_106330781 0.824 IGHV5-78
immunoglobulin heavy variable 5-78 pseudogene
chr2_+_87536174 0.823 NCRNA00152
non-protein coding RNA 152
chr7_+_29486010 0.823 NM_001039936
CHN2
chimerin (chimaerin) 2
chr6_+_26264531 0.820 HIST1H1E
histone cluster 1, H1e
chr3_+_45902999 0.807 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chrX_+_128741578 0.798 SASH3
SAM and SH3 domain containing 3
chr6_+_12824873 0.794 PHACTR1
phosphatase and actin regulator 1
chr1_+_149877955 0.789 SNX27
sorting nexin family member 27
chr9_-_139316523 0.775 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr14_+_38720085 0.767 PNN
pinin, desmosome associated protein
chr21_+_39117064 0.765 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr1_+_111217244 0.744 NM_000560
CD53
CD53 molecule
chrX_+_128741562 0.732 NM_018990
SASH3
SAM and SH3 domain containing 3
chr13_-_27441423 0.729 CDX2
caudal type homeobox 2
chr8_-_17797127 0.719 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr14_-_105804211 0.713 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_+_70831387 0.712 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr11_+_62813947 0.710 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr9_+_96561750 0.692 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr14_+_87560646 0.691 LOC283587
hypothetical protein LOC283587
chr5_-_176769094 0.689 F12
coagulation factor XII (Hageman factor)
chr1_+_111217314 0.688 CD53
CD53 molecule
chr4_+_39874921 0.677 NM_004310
RHOH
ras homolog gene family, member H
chr3_-_52839727 0.670 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr10_-_69267774 0.668 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr6_-_32605898 0.663 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr9_-_103185621 0.657 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr7_+_89681069 0.657 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr9_-_115877104 0.652 AMBP
alpha-1-microglobulin/bikunin precursor
chr7_+_45899621 0.651


chr15_-_76313896 0.645 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr2_-_233349469 0.644 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr14_+_31868229 0.638 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr4_+_187424336 0.636 F11
coagulation factor XI
chr14_-_105524207 0.625 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_80105718 0.623 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr4_-_176970372 0.617 GPM6A
glycoprotein M6A
chr14_-_20128721 0.617 NM_001024822
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr7_-_16811131 0.612 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr14_-_106154332 0.607 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_186970366 0.602 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr19_-_5790702 0.596 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr17_-_25685175 0.592 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr7_-_36730525 0.592 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr2_+_143351695 0.587 KYNU
kynureninase
chr1_+_156842852 0.587 NM_001004478
OR10Z1
olfactory receptor, family 10, subfamily Z, member 1
chrX_+_87888881 0.587 NM_001184771
NM_033048
CPXCR1

CPX chromosome region, candidate 1

chr4_+_74500748 0.585 ALB
albumin
chr11_+_8016755 0.583 NM_003320
TUB
tubby homolog (mouse)
chr10_+_7785347 0.581 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_+_102401580 0.570 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr4_-_123761615 0.570 NM_021803
IL21
interleukin 21
chr3_-_9895633 0.570 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr1_-_246503738 0.564 NM_001004695
OR2T33
olfactory receptor, family 2, subfamily T, member 33
chr5_+_118993152 0.561 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr4_-_110942783 0.558 NM_000204
CFI
complement factor I
chr1_-_120112989 0.558 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr6_+_12825022 0.554 PHACTR1
phosphatase and actin regulator 1
chr1_+_190552744 0.553 NM_001039152
RGS21
regulator of G-protein signaling 21
chr17_+_12564330 0.548 NM_001146313
MYOCD
myocardin
chr6_+_38798529 0.544 NM_001371
DNAH8
dynein, axonemal, heavy chain 8
chr1_+_50347188 0.542 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr19_+_7734034 0.541 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr10_-_5436781 0.540 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chrX_-_153698930 0.538 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr11_+_82078217 0.535


chr4_-_155731288 0.533 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr1_-_180627934 0.531 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr18_+_27425727 0.522 NM_000371
TTR
transthyretin
chr4_-_41445693 0.518 NM_003924
PHOX2B
paired-like homeobox 2b
chr2_-_37397669 0.517 NM_005813
PRKD3
protein kinase D3
chr6_-_167491305 0.515 NM_005299
GPR31
G protein-coupled receptor 31
chr5_-_1050408 0.515 LOC100506688
hypothetical protein LOC100506688
chr16_-_55111275 0.515 BBS2
Bardet-Biedl syndrome 2
chr2_+_132196533 0.514 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr5_-_176769141 0.512 NM_000505
F12
coagulation factor XII (Hageman factor)
chr3_+_123256902 0.512 NM_175862
CD86
CD86 molecule
chr12_-_103846186 0.509 NM_032148
SLC41A2
solute carrier family 41, member 2
chr19_-_62370667 0.508 NM_001012729
DUXA
double homeobox A
chr20_-_44151971 0.503 NM_020967
NCOA5
nuclear receptor coactivator 5
chr12_-_66839589 0.502 NM_000619
IFNG
interferon, gamma
chr9_+_130485926 0.502 SET
SET nuclear oncogene
chr2_-_188086612 0.501 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chrX_-_123925343 0.501 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr11_+_123945102 0.494 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr2_-_157890400 0.494 NM_020711
ERMN
ermin, ERM-like protein
chr2_+_135312655 0.492 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr2_-_43919392 0.491 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr19_+_59820413 0.489 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr5_+_161210280 0.485 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_+_6533932 0.482 NM_004271
LY86
lymphocyte antigen 86
chr8_-_27171814 0.481 NM_030795
STMN4
stathmin-like 4
chr19_+_56420131 0.479 NM_001082618
NM_001177608
NM_001772
CD33


CD33 molecule



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.61 2.86e-06 GO:0007606 sensory perception of chemical stimulus
2.67 7.38e-06 GO:0007608 sensory perception of smell
2.18 9.02e-06 GO:0006955 immune response
1.81 1.10e-04 GO:0002376 immune system process
1.26 1.03e-03 GO:0050896 response to stimulus
5.17 1.60e-03 GO:0072376 protein activation cascade
1.99 2.75e-03 GO:0002682 regulation of immune system process
1.89 3.48e-03 GO:0006952 defense response
2.23 5.44e-03 GO:0050776 regulation of immune response
1.27 7.30e-03 GO:0032501 multicellular organismal process
5.92 8.07e-03 GO:0031214 biomineral tissue development
2.20 1.02e-02 GO:0002684 positive regulation of immune system process
1.82 1.38e-02 GO:0007600 sensory perception

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.61 4.69e-06 GO:0005576 extracellular region
1.35 1.05e-04 GO:0005886 plasma membrane
1.34 1.33e-04 GO:0071944 cell periphery
1.62 1.85e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.74 7.48e-09 GO:0004871 signal transducer activity
1.74 7.48e-09 GO:0060089 molecular transducer activity
1.97 1.92e-08 GO:0004888 transmembrane receptor activity
1.78 1.56e-07 GO:0004872 receptor activity
2.16 3.17e-07 GO:0004930 G-protein coupled receptor activity
2.80 3.89e-07 GO:0004984 olfactory receptor activity